Tadpole-like conformations of huntingtin exon 1 are characterized by conformational heterogeneity that persists regardless of polyglutamine length

Soluble huntingtin exon 1 (Httex1) with expanded polyglutamine (polyQ) engenders neurotoxicity in Huntington’s disease. To uncover the physical basis of this toxicity, we performed structural studies of soluble Httex1 for wild type and mutant polyQ lengths. Nuclear magnetic resonance experiments sho...

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Udgivet i:J Mol Biol
Main Authors: Newcombe, Estella A., Ruff, Kiersten M., Sethi, Ashish, Ormsby, Angelique R., Ramdzan, Yasmin M., Fox, Archa, Purcell, Anthony W., Gooley, Paul R., Pappu, Rohit V., Hatters, Danny M.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5963539/
https://ncbi.nlm.nih.gov/pubmed/29627459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2018.03.031
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