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Cross-Seeding Fibrillation of Q/N-Rich Proteins Offers New Pathomechanism of Polyglutamine Diseases
A pathological hallmark of the Huntington's disease (HD) is intracellular inclusions containing a huntingtin (Htt) protein with an elongated polyglutamine tract. Aggregation of mutant Htt causes abnormal protein–protein interactions, and the functional dysregulation of aggregate-interacting pro...
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| Publicado no: | J Neurosci |
|---|---|
| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society for Neuroscience
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6665470/ https://ncbi.nlm.nih.gov/pubmed/19386911 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0783-09.2009 |
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