Mutation-dependent Polymorphism of Cu,Zn-Superoxide Dismutase Aggregates in the Familial Form of Amyotrophic Lateral Sclerosis

More than 100 different mutations in Cu,Zn-superoxide dismutase (SOD1) are linked to a familial form of amyotrophic lateral sclerosis (fALS). Pathogenic mutations facilitate fibrillar aggregation of SOD1, upon which significant structural changes of SOD1 have been assumed; in general, however, a str...

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Main Authors: Furukawa, Yoshiaki, Kaneko, Kumi, Yamanaka, Koji, Nukina, Nobuyuki
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Protein Structure and Folding
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903422/
https://ncbi.nlm.nih.gov/pubmed/20404329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.113597
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