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Redox environment is an intracellular factor to operate distinct pathways for aggregation of Cu,Zn-superoxide dismutase in amyotrophic lateral sclerosis
Dominant mutations in Cu,Zn-superoxide dismutase (SOD1) cause a familial form of amyotrophic lateral sclerosis (fALS). Misfolding and aggregation of mutant SOD1 proteins are a pathological hallmark of SOD1-related fALS cases; however, the molecular mechanism of SOD1 aggregation remains controversial...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3841916/ https://ncbi.nlm.nih.gov/pubmed/24348334 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2013.00240 |
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