A Seeding Reaction Recapitulates Intracellular Formation of Sarkosyl-insoluble Transactivation Response Element (TAR) DNA-binding Protein-43 Inclusions

The transactivation response element (TAR) DNA-binding protein-43 (TDP-43) is a nuclear protein that normally regulates transcription and splicing. Abnormal accumulation of insoluble inclusions containing TDP-43 has been recently reported in the affected tissues of amyotrophic lateral sclerosis (ALS...

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Bibliographic Details
Main Authors: Furukawa, Yoshiaki, Kaneko, Kumi, Watanabe, Shoji, Yamanaka, Koji, Nukina, Nobuyuki
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099683/
https://ncbi.nlm.nih.gov/pubmed/21454603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.231209
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