Intranuclear Degradation of Polyglutamine Aggregates by the Ubiquitin-Proteasome System

Huntington disease and its related autosomal-dominant polyglutamine (pQ) neurodegenerative diseases are characterized by intraneuronal accumulation of protein aggregates. Studies on protein aggregates have revealed the importance of the ubiquitin-proteasome system as the front line of protein qualit...

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Detalhes bibliográficos
Main Authors: Iwata, Atsushi, Nagashima, Yu, Matsumoto, Lumine, Suzuki, Takahiro, Yamanaka, Tomoyuki, Date, Hidetoshi, Deoka, Ken, Nukina, Nobuyuki, Tsuji, Shoji
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665101/
https://ncbi.nlm.nih.gov/pubmed/19218238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809739200
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