Substrate Ubiquitination Controls the Unfolding Ability of the Proteasome

In eukaryotic cells, proteins are targeted to the proteasome for degradation by polyubiquitination. These proteins bind to ubiquitin receptors, are engaged and unfolded by proteasomal ATPases, and are processively degraded. The factors determining to what extent the proteasome can successfully unfol...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Reichard, Eden L., Chirico, Giavanna G., Dewey, William J., Nassif, Nicholas D., Bard, Katelyn E., Millas, Nickolas E., Kraut, Daniel A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2016
Teme:
Protein Synthesis and Degradation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5000099/
https://ncbi.nlm.nih.gov/pubmed/27405762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.720151
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