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Slippery Substrates Impair ATP-dependent Protease Function by Slowing Unfolding
ATP-dependent proteases are responsible for most energy-dependent protein degradation across all species. Proteases initially bind an unstructured region on a substrate and then translocate along the polypeptide chain, unfolding and degrading protein domains as they are encountered. Although this pr...
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| Autor principal: | |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3843084/ https://ncbi.nlm.nih.gov/pubmed/24151080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.512533 |
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