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Slippery Substrates Impair Function of a Bacterial Protease ATPase by Unbalancing Translocation versus Exit
ATP-dependent proteases engage, translocate, and unfold substrate proteins. A sequence with only Gly and Ala residues (glycine-alanine repeat; GAr) encoded by the Epstein-Barr virus of humans inhibits eukaryotic proteasome activity. It causes the ATPase translocase to slip on its protein track, stal...
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| Hoofdauteurs: | , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Society for Biochemistry and Molecular Biology
2013
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3650364/ https://ncbi.nlm.nih.gov/pubmed/23530043 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.452524 |
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