Proteasomal conformation controls unfolding ability

The 26S proteasome is the macromolecular machine responsible for the bulk of protein degradation in eukaryotic cells. As it degrades a ubiquitinated protein, the proteasome transitions from a substrate-accepting conformation (s1) to a set of substrate-processing conformations (s3 like), each stabili...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Cresti, Julianna R., Manfredonia, Abramo J., Bragança, Christopher E., Boscia, Joseph A., Hurley, Christina M., Cundiff, Mary D., Kraut, Daniel A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2021
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8237680/
https://ncbi.nlm.nih.gov/pubmed/34161281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2101004118
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