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Proteasome inhibitors disrupt the unfolded protein response in myeloma cells

Novel agents that target the proteasome, a proteolytic complex responsible for the degradation of ubiquitinated proteins, have demonstrated remarkable therapeutic efficacy in multiple myeloma, a plasma cell malignancy. However, the mechanism by which these compounds act remains unknown. A signaling...

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書誌詳細
主要な著者: Lee, Ann-Hwee, Iwakoshi, Neal N., Anderson, Kenneth C., Glimcher, Laurie H.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2003
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC187896/
https://ncbi.nlm.nih.gov/pubmed/12902539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1334037100
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