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Proteasome inhibitors disrupt the unfolded protein response in myeloma cells
Novel agents that target the proteasome, a proteolytic complex responsible for the degradation of ubiquitinated proteins, have demonstrated remarkable therapeutic efficacy in multiple myeloma, a plasma cell malignancy. However, the mechanism by which these compounds act remains unknown. A signaling...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2003
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC187896/ https://ncbi.nlm.nih.gov/pubmed/12902539 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1334037100 |
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