Human Cytomegalovirus Protein US11 Provokes an Unfolded Protein Response That May Facilitate the Degradation of Class I Major Histocompatibility Complex Products

The human cytomegalovirus (HCMV) glycoprotein US11 diverts class I major histocompatibility complex (MHC) heavy chains (HC) from the endoplasmic reticulum (ER) to the cytosol, where HC are subjected to proteasome-mediated degradation. In mouse embryonic fibroblasts that are deficient for X-box bindi...

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Main Authors: Tirosh, Boaz, Iwakoshi, Neal N., Lilley, Brendan N., Lee, Ann-Hwee, Glimcher, Laurie H., Ploegh, Hidde L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2005
Assuntos:
Virus-Cell Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC548438/
https://ncbi.nlm.nih.gov/pubmed/15708995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.5.2768-2779.2005
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