Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells

Multiple myeloma (MM) is an incurable plasma cell malignancy. The 26S proteasome inhibitor, bortezomib, selectively induces apoptosis in MM cells; however, the nature of its selectivity remains unknown. Here we demonstrate that 5 different MM cell lines display similar patterns of sensitivity to 3 p...

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Autores principales: Obeng, Esther A., Carlson, Louise M., Gutman, Delia M., Harrington, William J., Lee, Kelvin P., Boise, Lawrence H.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society of Hematology 2006
Materias:
Neoplasia
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895817/
https://ncbi.nlm.nih.gov/pubmed/16507771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-08-3531
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