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CpG Demethylation Enhances Alpha-Synuclein Expression and Affects the Pathogenesis of Parkinson's Disease

BACKGROUND: Alpha-synuclein (SNCA) gene expression is an important factor in the pathogenesis of Parkinson's disease (PD). Gene multiplication can cause inherited PD, and promoter polymorphisms that increase SNCA expression are associated with sporadic PD. CpG methylation in the promoter region...

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Autors principals: Matsumoto, Lumine, Takuma, Hiroshi, Tamaoka, Akira, Kurisaki, Hiroshi, Date, Hidetoshi, Tsuji, Shoji, Iwata, Atsushi
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2991358/
https://ncbi.nlm.nih.gov/pubmed/21124796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015522
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