Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation

Huntington’s disease (HD) is an incurable neurodegenerative disease caused by neuronal accumulation of the mutant protein huntingtin. Improving clearance of the mutant protein is expected to prevent cellular dysfunction and neurodegeneration in HD. We report here that such clearance can be achieved...

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Hauptverfasser: Jeong, Hyunkyung, Then, Florian, Melia, Thomas J., Mazzulli, Joseph R., Cui, Libin, Savas, Jeffrey N., Voisine, Cindy, Paganetti, Paolo, Tanese, Naoko, Hart, Anne C., Yamamoto, Ai, Krainc, Dimitri
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940108/
https://ncbi.nlm.nih.gov/pubmed/19345187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.03.018
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