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Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease
Mitochondrial and lysosomal dysfunction have been implicated in substantia nigra dopaminergic neurodegeneration in Parkinson’s disease (PD), but how these pathways are linked in human neurons remains unclear. Here we studied dopaminergic neurons derived from patients with idiopathic and familial PD....
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| Опубликовано в: : | Science |
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| Главные авторы: | , , , , , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6021018/ https://ncbi.nlm.nih.gov/pubmed/28882997 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aam9080 |
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