Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

Mitochondrial and lysosomal dysfunction have been implicated in substantia nigra dopaminergic neurodegeneration in Parkinson’s disease (PD), but how these pathways are linked in human neurons remains unclear. Here we studied dopaminergic neurons derived from patients with idiopathic and familial PD....

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Publicado no:Science
Main Authors: Burbulla, Lena F., Song, Pingping, Mazzulli, Joseph R., Zampese, Enrico, Wong, Yvette C., Jeon, Sohee, Santos, David P., Blanz, Judith, Obermaier, Carolin D., Strojny, Chelsee, Savas, Jeffrey N., Kiskinis, Evangelos, Zhuang, Xiaoxi, Krüger, Rejko, Surmeier, D. James, Krainc, Dimitri
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6021018/
https://ncbi.nlm.nih.gov/pubmed/28882997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aam9080
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