Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons

Parkinson's disease (PD) is characterized by the accumulation of α-synuclein (α-syn) within Lewy body inclusions in the nervous system. There are currently no disease-modifying therapies capable of reducing α-syn inclusions in PD. Recent data has indicated that loss-of-function mutations in the...

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發表在:J Neurosci
Main Authors: Mazzulli, Joseph R., Zunke, Friederike, Tsunemi, Taiji, Toker, Nicholas J., Jeon, Sohee, Burbulla, Lena F., Patnaik, Samarjit, Sidransky, Ellen, Marugan, Juan J., Sue, Carolyn M., Krainc, Dimitri
格式: Artigo
語言:Inglês
出版: Society for Neuroscience 2016
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Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4951575/
https://ncbi.nlm.nih.gov/pubmed/27445146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0628-16.2016
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