Characterization of the complex formed by β-glucocerebrosidase and the lysosomal integral membrane protein type-2

The lysosomal integral membrane protein type-2 (LIMP-2) plays a pivotal role in the delivery of β-glucocerebrosidase (GC) to lysosomes. Mutations in GC result in Gaucher's disease (GD) and are the major genetic risk factor for the development of Parkinson's disease (PD). Variants in the LI...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Zunke, Friederike, Andresen, Lisa, Wesseler, Sophia, Groth, Johann, Arnold, Philipp, Rothaug, Michelle, Mazzulli, Joseph R., Krainc, Dimitri, Blanz, Judith, Saftig, Paul, Schwake, Michael
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2016
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833265/
https://ncbi.nlm.nih.gov/pubmed/27001828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1514005113
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