LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson’s disease patients

Mutations in LRRK2 and GBA1 are common genetic risk factors for Parkinson’s disease (PD) and major efforts are underway to develop new therapeutics that target LRRK2 or glucocerebrosidase (GCase). Here we describe a mechanistic and therapeutic convergence of LRRK2 and GCase in neurons derived from p...

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Detalhes bibliográficos
Publicado no:Nat Commun
Principais autores: Ysselstein, Daniel, Nguyen, Maria, Young, Tiffany J., Severino, Alex, Schwake, Michael, Merchant, Kalpana, Krainc, Dimitri
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6895201/
https://ncbi.nlm.nih.gov/pubmed/31804465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13413-w
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