Loading...

LRRK2 phosphorylation of auxilin mediates synaptic defects in dopaminergic neurons from patients with Parkinson’s disease

Recently identified Parkinson’s disease (PD) genes involved in synaptic vesicle endocytosis, such as DNAJC6 (auxilin), have further implicated synaptic dysfunction in PD pathogenesis. However, how synaptic dysfunction contributes to the vulnerability of human dopaminergic neurons has not been previo...

Full description

Saved in:
Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Nguyen, Maria, Krainc, Dimitri
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003526/
https://ncbi.nlm.nih.gov/pubmed/29735704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1717590115
Tags: Add Tag
No Tags, Be the first to tag this record!