LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson’s disease

Mutations in LRRK2 are thus far the most frequent known cause of autosomal dominant and idiopathic Parkinson’s disease (PD) with prevalent mutations being found within the GTPase (R1441C/G) and kinase (G2019S) domains. Previous in vitro studies have revealed that R1441C and G2019S mutations are asso...

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Bibliografiske detaljer
Main Authors: Yao, Chen, Khoury, Rabih El, Wang, Wen, Byrd, Tara A., Pehek, Elizabeth A., Thacker, Colin, Zhu, Xiongwei, Smith, Mark A., Wilson-Delfosse, Amy L., Chen, Shu G.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2926296/
https://ncbi.nlm.nih.gov/pubmed/20382224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2010.04.002
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