LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson’s disease

Mutations in LRRK2 are thus far the most frequent known cause of autosomal dominant and idiopathic Parkinson’s disease (PD) with prevalent mutations being found within the GTPase (R1441C/G) and kinase (G2019S) domains. Previous in vitro studies have revealed that R1441C and G2019S mutations are asso...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Yao, Chen, Khoury, Rabih El, Wang, Wen, Byrd, Tara A., Pehek, Elizabeth A., Thacker, Colin, Zhu, Xiongwei, Smith, Mark A., Wilson-Delfosse, Amy L., Chen, Shu G.
Format: Artigo
Langue:Inglês
Publié: 2010
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2926296/
https://ncbi.nlm.nih.gov/pubmed/20382224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2010.04.002
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires