LRRK2 Modulates Vulnerability to Mitochondrial Dysfunction in Caenorhabditis elegans

Mutations in leucine-rich repeat kinase 2 (LRRK2) cause autosomal-dominant familial Parkinson's disease. We generated lines of Caenorhabditis elegans expressing neuronally directed human LRRK2. Expressing human LRRK2 increased nematode survival in response to rotenone or paraquat, which are age...

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Detalhes bibliográficos
Main Authors: Saha, Shamol, Guillily, Maria D., Ferree, Andrew, Lanceta, Joel, Chan, Diane, Ghosh, Joy, Hsu, Cindy H., Segal, Lilach, Raghavan, Kesav, Matsumoto, Kunihiro, Hisamoto, Naoki, Kuwahara, Tomoki, Iwatsubo, Takeshi, Moore, Landon, Goldstein, Lee, Cookson, Mark, Wolozin, Benjamin
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3127548/
https://ncbi.nlm.nih.gov/pubmed/19625511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2281-09.2009
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