LRRK2 Modulates Vulnerability to Mitochondrial Dysfunction in Caenorhabditis elegans

Mutations in leucine-rich repeat kinase 2 (LRRK2) cause autosomal-dominant familial Parkinson's disease. We generated lines of Caenorhabditis elegans expressing neuronally directed human LRRK2. Expressing human LRRK2 increased nematode survival in response to rotenone or paraquat, which are age...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Saha, Shamol, Guillily, Maria D., Ferree, Andrew, Lanceta, Joel, Chan, Diane, Ghosh, Joy, Hsu, Cindy H., Segal, Lilach, Raghavan, Kesav, Matsumoto, Kunihiro, Hisamoto, Naoki, Kuwahara, Tomoki, Iwatsubo, Takeshi, Moore, Landon, Goldstein, Lee, Cookson, Mark, Wolozin, Benjamin
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Society for Neuroscience 2009
विषय:
Articles
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3127548/
https://ncbi.nlm.nih.gov/pubmed/19625511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2281-09.2009
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