LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts

Leucine-rich repeat kinase 2 (LRRK2) has been linked to several clinical disorders including Parkinson’s disease (PD), Crohn’s disease, and leprosy. Furthermore in rodents, LRRK2 deficiency or inhibition leads to lysosomal pathology in kidney and lung. Here we provide evidence that LRRK2 functions t...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kuwahara, Tomoki, Inoue, Keiichi, D’Agati, Vivette D., Fujimoto, Tetta, Eguchi, Tomoya, Saha, Shamol, Wolozin, Benjamin, Iwatsubo, Takeshi, Abeliovich, Asa
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4947924/
https://ncbi.nlm.nih.gov/pubmed/27424887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29945
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados