LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis

Leucine-rich repeat kinase 2 (LRRK2) has been associated with a variety of human diseases, including Parkinson’s disease and Crohn’s disease, whereas LRRK2 deficiency leads to accumulation of abnormal lysosomes in aged animals. However, the cellular roles and mechanisms of LRRK2-mediated lysosomal r...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Eguchi, Tomoya, Kuwahara, Tomoki, Sakurai, Maria, Komori, Tadayuki, Fujimoto, Tetta, Ito, Genta, Yoshimura, Shin-ichiro, Harada, Akihiro, Fukuda, Mitsunori, Koike, Masato, Iwatsubo, Takeshi
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6166828/
https://ncbi.nlm.nih.gov/pubmed/30209220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1812196115
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados