LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance

Mutations within the lysosomal enzyme β-glucocerebrosidase (GC) result in Gaucher disease and represent a major risk factor for developing Parkinson disease (PD). Loss of GC activity leads to accumulation of its substrate glucosylceramide and α-synuclein. Since lysosomal activity of GC is tightly li...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Rothaug, Michelle, Zunke, Friederike, Mazzulli, Joseph R., Schweizer, Michaela, Altmeppen, Hermann, Lüllmann-Rauch, Renate, Kallemeijn, Wouter W., Gaspar, Paulo, Aerts, Johannes M., Glatzel, Markus, Saftig, Paul, Krainc, Dimitri, Schwake, Michael, Blanz, Judith
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2014
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217458/
https://ncbi.nlm.nih.gov/pubmed/25316793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1405700111
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia