Modeling neuronopathic storage diseases with patient-derived culture systems

Por Zunke, Friederike, Mazzulli, Joseph R.
Publicado no Neurobiol Dis (2019)

α-Synuclein–induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models

Por Mazzulli, Joseph R., Zunke, Friederike, Isacson, Ole, Studer, Lorenz, Krainc, Dimitri
Publicado no Proc Natl Acad Sci U S A (2016)

Alpha Synuclein Connects the Gut-Brain Axis in Parkinson’s Disease Patients – A View on Clinical Aspects, Cellular Pathology and Analytical Methodology

Por Schaeffer, Eva, Kluge, Annika, Böttner, Martina, Zunke, Friederike, Cossais, Francois, Berg, Daniela, Arnold, Philipp
Publicado no Front Cell Dev Biol (2020)

Functional Characterization of Colon Cancer-Associated Mutations in ADAM17: Modifications in the Pro-Domain Interfere with Trafficking and Maturation

Por Pavlenko, Egor, Cabron, Anne-Sophie, Arnold, Philipp, Dobert, Jan Philipp, Rose-John, Stefan, Zunke, Friederike
Publicado no Int J Mol Sci (2019)

LAMP-2 deficiency leads to hippocampal dysfunction but normal clearance of neuronal substrates of chaperone-mediated autophagy in a mouse model for Danon disease

Por Rothaug, Michelle, Stroobants, Stijn, Schweizer, Michaela, Peters, Judith, Zunke, Friederike, Allerding, Mirka, D’Hooge, Rudi, Saftig, Paul, Blanz, Judith
Publicado no Acta Neuropathol Commun (2015)

Pharmacological dissection of K(v)7.1 channels in systemic and pulmonary arteries

Por Chadha, Preet S, Zunke, Friederike, Davis, Alison J, Jepps, Thomas A, Linders, Joannes TM, Schwake, Michael, Towart, Rob, Greenwood, Iain A
Publicado em 2012

Characterization of the complex formed by β-glucocerebrosidase and the lysosomal integral membrane protein type-2

Por Zunke, Friederike, Andresen, Lisa, Wesseler, Sophia, Groth, Johann, Arnold, Philipp, Rothaug, Michelle, Mazzulli, Joseph R., Krainc, Dimitri, Blanz, Judith, Saftig, Paul, Schwake, Michael
Publicado no Proc Natl Acad Sci U S A (2016)

Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by Glucosylceramide

Por Zunke, Friederike, Moise, Alexandra C., Belur, Nandkishore R., Gelyana, Eilrayna, Stojkovska, Iva, Dzaferbegovic, Haris, Toker, Nicholas J., Jeon, Sohee, Fredriksen, Kristina, Mazzulli, Joseph R.
Publicado no Neuron (2017)

Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons

Por Mazzulli, Joseph R., Zunke, Friederike, Tsunemi, Taiji, Toker, Nicholas J., Jeon, Sohee, Burbulla, Lena F., Patnaik, Samarjit, Sidransky, Ellen, Marugan, Juan J., Sue, Carolyn M., Krainc, Dimitri
Publicado no J Neurosci (2016)

Action myoclonus-renal failure syndrome: diagnostic applications of activity-based probes and lipid analysis

Por Gaspar, Paulo, Kallemeijn, Wouter W., Strijland, Anneke, Scheij, Saskia, Van Eijk, Marco, Aten, Jan, Overkleeft, Herman S., Balreira, Andrea, Zunke, Friederike, Schwake, Michael, Sá Miranda, Clara, Aerts, Johannes M. F. G.
Publicado em 2014

LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance

Por Rothaug, Michelle, Zunke, Friederike, Mazzulli, Joseph R., Schweizer, Michaela, Altmeppen, Hermann, Lüllmann-Rauch, Renate, Kallemeijn, Wouter W., Gaspar, Paulo, Aerts, Johannes M., Glatzel, Markus, Saftig, Paul, Krainc, Dimitri, Schwake, Michael, Blanz, Judith
Publicado em 2014

Structural and Functional Analyses of the Shedding Protease ADAM17 in HoxB8-Immortalized Macrophages and Dendritic-like Cells

Por Cabron, Anne-Sophie, El azzouzi, Karim, Boss, Melanie, Arnold, Philipp, Schwarz, Jeanette, Rosas, Marcela, Dobert, Jan Philipp, Pavlenko, Egor, Schumacher, Neele, Renné, Thomas, Taylor, Philip R., Linder, Stefan, Rose-John, Stefan, Zunke, Friederike
Publicado no J Immunol (2018)

Stress-induced cellular clearance is mediated by SNARE protein ykt6 and disrupted by a-synuclein

Por Cuddy, Leah K., Wani, Willayat Y., Morella, Martino L., Pitcairn, Caleb, Tsutsumi, Kotaro, Fredriksen, Kristina, Justman, Craig J., Grammatopoulos, Tom N., Belur, Nandkishore R., Zunke, Friederike, Subramanian, Aarthi, Affaneh, Amira, Lansbury, Peter T., Mazzulli, Joseph R.
Publicado no Neuron (2019)

ADAM17 is required for EGF-R–induced intestinal tumors via IL-6 trans-signaling

Por Schmidt, Stefanie, Schumacher, Neele, Schwarz, Jeanette, Tangermann, Simone, Kenner, Lukas, Schlederer, Michaela, Sibilia, Maria, Linder, Markus, Altendorf-Hofmann, Annelore, Knösel, Thomas, Gruber, Elisabeth S., Oberhuber, Georg, Bolik, Julia, Rehman, Ateequr, Sinha, Anupam, Lokau, Juliane, Arnold, Philipp, Cabron, Anne-Sophie, Zunke, Friederike, Becker-Pauly, Christoph, Preaudet, Adele, Nguyen, Paul, Huynh, Jennifer, Afshar-Sterle, Shoukat, Chand, Ashwini L., Westermann, Jürgen, Dempsey, Peter J., Garbers, Christoph, Schmidt-Arras, Dirk, Rosenstiel, Philip, Putoczki, Tracy, Ernst, Matthias, Rose-John, Stefan
Publicado no J Exp Med (2018)