Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by Glucosylceramide

α-Synuclein (α-Syn) aggregation is a key event in Parkinson's disease (PD). Mutations in glycosphin-golipid (GSL)-degrading glucocerebrosidase are risk factors for PD, indicating that disrupted GSL clearance plays a key role in α-Syn aggregation. However, the mechanisms of GSL-induced aggregati...

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Detalhes bibliográficos
Publicado no:Neuron
Main Authors: Zunke, Friederike, Moise, Alexandra C., Belur, Nandkishore R., Gelyana, Eilrayna, Stojkovska, Iva, Dzaferbegovic, Haris, Toker, Nicholas J., Jeon, Sohee, Fredriksen, Kristina, Mazzulli, Joseph R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6013314/
https://ncbi.nlm.nih.gov/pubmed/29290548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2017.12.012
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