Stress-induced cellular clearance is mediated by SNARE protein ykt6 and disrupted by a-synuclein

Age-related neurodegenerative disorders are characterized by slow, persistent accumulation of aggregated proteins. Although cells can elicit physiological responses to enhance cellular clearance and counteract accumulation, it is unclear how pathogenic proteins evade this process in disease. We find...

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Detalhes bibliográficos
Publicado no:Neuron
Main Authors: Cuddy, Leah K., Wani, Willayat Y., Morella, Martino L., Pitcairn, Caleb, Tsutsumi, Kotaro, Fredriksen, Kristina, Justman, Craig J., Grammatopoulos, Tom N., Belur, Nandkishore R., Zunke, Friederike, Subramanian, Aarthi, Affaneh, Amira, Lansbury, Peter T., Mazzulli, Joseph R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6895429/
https://ncbi.nlm.nih.gov/pubmed/31648898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2019.09.001
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