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Dysregulation of the autophagic-lysosomal pathway in Gaucher and Parkinson’s disease

The finding that mutations in the Gaucher’s Disease (GD) gene GBA1 are a strong risk factor for Parkinson’s Disease (PD) has allowed for unique insights into pathophysiology centered on disruption of the autophagic-lysosomal pathway. Protein aggregations in the form of Lewy bodies and the effects of...

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Detalhes bibliográficos
Publicado no:Neurobiol Dis
Main Authors: Pitcairn, Caleb, Wani, Willayat Yousuf, Mazzulli, Joseph R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6138580/
https://ncbi.nlm.nih.gov/pubmed/29550539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2018.03.008
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