Stress-induced cellular clearance is mediated by SNARE protein ykt6 and disrupted by a-synuclein

Age-related neurodegenerative disorders are characterized by slow, persistent accumulation of aggregated proteins. Although cells can elicit physiological responses to enhance cellular clearance and counteract accumulation, it is unclear how pathogenic proteins evade this process in disease. We find...

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Опубликовано в: :Neuron
Главные авторы: Cuddy, Leah K., Wani, Willayat Y., Morella, Martino L., Pitcairn, Caleb, Tsutsumi, Kotaro, Fredriksen, Kristina, Justman, Craig J., Grammatopoulos, Tom N., Belur, Nandkishore R., Zunke, Friederike, Subramanian, Aarthi, Affaneh, Amira, Lansbury, Peter T., Mazzulli, Joseph R.
Формат: Artigo
Язык:Inglês
Опубликовано: 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6895429/
https://ncbi.nlm.nih.gov/pubmed/31648898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2019.09.001
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