Evolution of amyloid: What normal protein folding may tell us about fibrillogenesis and disease

Por Lansbury, Peter T.
Publicado em 1999

A possible therapeutic target for Lou Gehrig's disease

Por Ray, Soumya S., Lansbury, Peter T.
Publicado em 2004

A computer program for the estimation of protein and nucleic acid sequence diversity in random point mutagenesis libraries

Por Volles, Michael J., Lansbury, Peter T.
Publicado em 2005

Relationships between the sequence of α-synuclein and its membrane affinity, fibrillization propensity, and yeast toxicity

Por Volles, Michael J., Lansbury, Peter T.
Publicado em 2006

N-terminal deletion does not affect α-synuclein membrane binding, self-association and toxicity in human neuroblastoma cells, unlike yeast

Por Vamvaca, Katherina, Lansbury, Peter T., Stefanis, Leonidas
Publicado em 2011

The First N-terminal Amino Acids of α-Synuclein Are Essential for α-Helical Structure Formation In Vitro and Membrane Binding in Yeast

Por Vamvaca, Katherina, Volles, Michael J., Lansbury, Peter T.
Publicado em 2009

Amyloid diseases: Abnormal protein aggregation in neurodegeneration

Por Koo, Edward H., Lansbury, Peter T., Kelly, Jeffery W.
Publicado em 1999

Small-molecule-mediated stabilization of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants against unfolding and aggregation

Por Ray, Soumya S., Nowak, Richard J., Brown, Robert H., Lansbury, Peter T.
Publicado em 2005

Improving binding specificity of pharmacological chaperones that target mutant superoxide dismutase-1 linked to familial amyotrophic lateral sclerosis using computational methods

Por Nowak, Richard J., Cuny, Gregory D., Choi, Sungwoon, Lansbury, Peter T., Ray, Soumya S.
Publicado em 2010

Acceleration of oligomerization, not fibrillization, is a shared property of both α-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis a...

Por Conway, Kelly A., Lee, Seung-Jae, Rochet, Jean-Christophe, Ding, Tomas T., Williamson, Robin E., Lansbury, Peter T.
Publicado em 2000

Membrane-associated farnesylated UCH-L1 promotes α-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease

Por Liu, Zhihua, Meray, Robin K., Grammatopoulos, Tom N., Fredenburg, Ross A., Cookson, Mark R., Liu, Yichin, Logan, Todd, Lansbury, Peter T.
Publicado em 2009

Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1

Por Das, Chittaranjan, Hoang, Quyen Q., Kreinbring, Cheryl A., Luchansky, Sarah J., Meray, Robin K., Ray, Soumya S., Lansbury, Peter T., Ringe, Dagmar, Petsko, Gregory A.
Publicado em 2006

Phosphorylation at Ser-129 but Not the Phosphomimics S129E/D Inhibits the Fibrillation of α-Synuclein

Por Paleologou, Katerina E., Schmid, Adrian W., Rospigliosi, Carla C., Kim, Hai-Young, Lamberto, Gonzalo R., Fredenburg, Ross A., Lansbury, Peter T., Fernandez, Claudio O., Eliezer, David, Zweckstetter, Markus, Lashuel, Hilal A.
Publicado em 2008

Dissociation of amyloid fibrils of α-synuclein and transthyretin by pressure reveals their reversible nature and the formation of water-excluded cavities

Por Foguel, Débora, Suarez, Marisa C., Ferrão-Gonzales, Astria D., Porto, Thais C. R., Palmieri, Leonardo, Einsiedler, Carla M., Andrade, Leonardo R., Lashuel, Hilal A., Lansbury, Peter T., Kelly, Jeffery W., Silva, Jerson L.
Publicado em 2003

Dopamine-modified α-synuclein blocks chaperone-mediated autophagy

Por Martinez-Vicente, Marta, Talloczy, Zsolt, Kaushik, Susmita, Massey, Ashish C., Mazzulli, Joseph, Mosharov, Eugene V., Hodara, Roberto, Fredenburg, Ross, Wu, Du-Chu, Follenzi, Antonia, Dauer, William, Przedborski, Serge, Ischiropoulos, Harry, Lansbury, Peter T., Sulzer, David, Cuervo, Ana Maria
Publicado em 2008

Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form

Por Collier, Timothy J., Srivastava, Kinshuk R., Justman, Craig, Grammatopoulous, Tom, Hutter-Paier, Birgit, Prokesch, Manuela, Havas, Daniel, Rochet, Jean-Christophe, Liu, Fang, Jock, Kevin, de Oliveira, Patrícia, Stirtz, Georgia L., Dettmer, Ulf, Sortwell, Caryl E., Feany, Mel B., Lansbury, Peter, Lapidus, Lisa, Paumier, Katrina L.
Publicado no Neurobiol Dis (2017)