ExPLAining early synucleinopathies

Por Dettmer, Ulf, Bartels, Tim
Publicado no Brain (2015)

A New Method for Quantitative Immunoblotting of Endogenous α-Synuclein

Por Newman, Andrew J., Selkoe, Dennis, Dettmer, Ulf
Publicado em 2013

In Vivo Cross-linking Reveals Principally Oligomeric Forms of α-Synuclein and β-Synuclein in Neurons and Non-neural Cells

Por Dettmer, Ulf, Newman, Andrew J., Luth, Eric S., Bartels, Tim, Selkoe, Dennis
Publicado em 2013

Purification of α-Synuclein from Human Brain Reveals an Instability of Endogenous Multimers as the Protein Approaches Purity

Por Luth, Eric S., Bartels, Tim, Dettmer, Ulf, Kim, Nora C., Selkoe, Dennis J.
Publicado no Biochemistry (2014)

KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity

Por Dettmer, Ulf, Newman, Andrew J., von Saucken, Victoria E., Bartels, Tim, Selkoe, Dennis
Publicado no Proc Natl Acad Sci U S A (2015)

Transmembrane Protein 147 (TMEM147) Is a Novel Component of the Nicalin-NOMO Protein Complex

Por Dettmer, Ulf, Kuhn, Peer-Hendrik, Abou-Ajram, Claudia, Lichtenthaler, Stefan F., Krüger, Marcus, Kremmer, Elisabeth, Haass, Christian, Haffner, Christof
Publicado em 2010

Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation

Por Dettmer, Ulf, Newman, Andrew J., Soldner, Frank, Luth, Eric S., Kim, Nora C., von Saucken, Victoria E., Sanderson, John B., Jaenisch, Rudolf, Bartels, Tim, Selkoe, Dennis
Publicado no Nat Commun (2015)

Corrigendum: Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation

Por Dettmer, Ulf, Newman, Andrew J., Soldner, Frank, Luth, Eric S., Kim, Nora C., von Saucken, Victoria E., Sanderson, John B., Jaenisch, Rudolf, Bartels, Tim, Selkoe, Dennis
Publicado no Nat Commun (2015)

Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells

Por Dettmer, Ulf, Ramalingam, Nagendran, von Saucken, Victoria E., Kim, Tae-Eun, Newman, Andrew J., Terry-Kantor, Elizabeth, Nuber, Silke, Ericsson, Maria, Fanning, Saranna, Bartels, Tim, Lindquist, Susan, Levy, Oren A., Selkoe, Dennis
Publicado no Hum Mol Genet (2017)

Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form

Por Collier, Timothy J., Srivastava, Kinshuk R., Justman, Craig, Grammatopoulous, Tom, Hutter-Paier, Birgit, Prokesch, Manuela, Havas, Daniel, Rochet, Jean-Christophe, Liu, Fang, Jock, Kevin, de Oliveira, Patrícia, Stirtz, Georgia L., Dettmer, Ulf, Sortwell, Caryl E., Feany, Mel B., Lansbury, Peter, Lapidus, Lisa, Paumier, Katrina L.
Publicado no Neurobiol Dis (2017)