Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form

The pathology of Parkinson’s disease and other synucleinopathies is characterized by the formation of intracellular inclusions comprised primarily of misfolded, fibrillar α-synuclein (α-syn). One strategy to slow disease progression is to prevent the misfolding and aggregation of its native monomeri...

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Veröffentlicht in:Neurobiol Dis
Hauptverfasser: Collier, Timothy J., Srivastava, Kinshuk R., Justman, Craig, Grammatopoulous, Tom, Hutter-Paier, Birgit, Prokesch, Manuela, Havas, Daniel, Rochet, Jean-Christophe, Liu, Fang, Jock, Kevin, de Oliveira, Patrícia, Stirtz, Georgia L., Dettmer, Ulf, Sortwell, Caryl E., Feany, Mel B., Lansbury, Peter, Lapidus, Lisa, Paumier, Katrina L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5793922/
https://ncbi.nlm.nih.gov/pubmed/28711409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2017.07.007
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