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Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation
β-Sheet-rich α-synuclein (αS) aggregates characterize Parkinson's disease (PD). αS was long believed to be a natively unfolded monomer, but recent work suggests it also occurs in α-helix-rich tetramers. Crosslinking traps principally tetrameric αS in intact normal neurons, but not after cell ly...
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| Izdano u: | Nat Commun |
|---|---|
| Glavni autori: | , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Pub. Group
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4490410/ https://ncbi.nlm.nih.gov/pubmed/26076669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8314 |
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