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Abrogating native α-synuclein tetramers in mice causes a L-DOPA responsive motor syndrome closely resembling Parkinson’s disease

α-Synuclein (αS) regulates vesicle exocytosis but forms insoluble deposits in Parkinson’s disease. Developing disease-modifying therapies requires animal models that reproduce cardinal features of PD. We recently described a previously unrecognized physiological form of αS, α-helical tetramers, and...

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Bibliografiske detaljer
Udgivet i:Neuron
Main Authors: Nuber, Silke, Rajsombath, Molly, Minakaki, Georgia, Winkler, Jürgen, Müller, Christian P., Ericsson, Maria, Caldarone, Barbara, Dettmer, Ulf, Selkoe, Dennis J.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6211795/
https://ncbi.nlm.nih.gov/pubmed/30308173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2018.09.014
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