Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells

α-Synuclein (αS) forms round cytoplasmic inclusions in Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). Evidence suggests a physiological function of αS in vesicle trafficking and release. In contrast to earlier tenets, recent work indicates that αS normally exists in cells in a dynamic...

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Publicado en:Hum Mol Genet
Autores principales: Dettmer, Ulf, Ramalingam, Nagendran, von Saucken, Victoria E., Kim, Tae-Eun, Newman, Andrew J., Terry-Kantor, Elizabeth, Nuber, Silke, Ericsson, Maria, Fanning, Saranna, Bartels, Tim, Lindquist, Susan, Levy, Oren A., Selkoe, Dennis
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2017
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5884392/
https://ncbi.nlm.nih.gov/pubmed/28911198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx227
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