Lanean...
Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation
β-Sheet-rich α-synuclein (αS) aggregates characterize Parkinson's disease (PD). αS was long believed to be a natively unfolded monomer, but recent work suggests it also occurs in α-helix-rich tetramers. Crosslinking traps principally tetrameric αS in intact normal neurons, but not after cell ly...
Gorde:
| Argitaratua izan da: | Nat Commun |
|---|---|
| Egile Nagusiak: | , , , , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Nature Pub. Group
2015
|
| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4490410/ https://ncbi.nlm.nih.gov/pubmed/26076669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8314 |
| Etiketak: |
Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!
|