Pathway for Parkinson disease

von Hoang, Quyen Q.
Veröffentlicht 2014

Combating Parkinson’s disease-associated toxicity by modulating proteostasis

von Park, Yangshin, Hoang, Quyen Q.
Veröffentlicht in Proc Natl Acad Sci U S A (2017)

Roco Proteins and the Parkinson’s Disease-Associated LRRK2

von Liao, Jingling, Hoang, Quyen Q.
Veröffentlicht in Int J Mol Sci (2018)

Hydrophilic Residues Are Crucial for Ribosomal Protein L11 (RPL11) Interaction with Zinc Finger Domain of MDM2 and p53 Protein Activation

von Zhang, Qi, Xiao, Hui, Chai, Sergio C., Hoang, Quyen Q., Lu, Hua
Veröffentlicht 2011

The Parkinson's disease–associated mutation N1437H impairs conformational dynamics in the G domain of LRRK2

von Huang, Xiaorong, Wu, Chunxiang, Park, Yangshin, Long, Xuwei, Hoang, Quyen Q., Liao, Jingling
Veröffentlicht in FASEB J (2019)

Structural and Biochemical Characterization of AidC, a Quorum-Quenching Lactonase With Atypical Selectivity

von Mascarenhas, Romila, Thomas, Pei W., Wu, Chun-Xiang, Nocek, Boguslaw P., Hoang, Quyen Q., Liu, Dali, Fast, Walter
Veröffentlicht in Biochemistry (2015)

Zinc Coordination Geometry and Ligand Binding Affinity: The Structural and Kinetic Analysis of the Second-Shell Serine 228 Residue and the Methionine 180 Residue of the Aminopeptid...

von Ataie, Niloufar J., Hoang, Quyen Q., Zahniser, Megan P.D., Tu, Yupeng, Milne, Amy, Petsko, Gregory A., Ringe, Dagmar
Veröffentlicht 2008

Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1

von Das, Chittaranjan, Hoang, Quyen Q., Kreinbring, Cheryl A., Luchansky, Sarah J., Meray, Robin K., Ray, Soumya S., Lansbury, Peter T., Ringe, Dagmar, Petsko, Gregory A.
Veröffentlicht 2006

Potential pharmacological chaperones targeting cancer-associated MCL-1 and Parkinson disease-associated α-synuclein

von Oh, Misook, Lee, Ji Hoon, Wang, Wei, Lee, Hui Sun, Lee, Woo Sirl, Burlak, Christopher, Im, Wonpil, Hoang, Quyen Q., Lim, Hyun-Suk
Veröffentlicht 2014

Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy

von Bassil, Fares, Fernagut, Pierre-Olivier, Bezard, Erwan, Pruvost, Alain, Leste-Lasserre, Thierry, Hoang, Quyen Q., Ringe, Dagmar, Petsko, Gregory A., Meissner, Wassilios G.
Veröffentlicht in Proc Natl Acad Sci U S A (2016)

Discovery and optimization of inhibitors of the Parkinson’s disease associated protein DJ-1

von Tashiro, Shinya, Caaveiro, Jose M. M., Nakakido, Makoto, Tanabe, Aki, Nagatoishi, Satoru, Tamura, Yasushi, Matsuda, Noriyuki, Liu, Dali, Hoang, Quyen Q., Tsumoto, Kouhei
Veröffentlicht in ACS Chem Biol (2018)

Analogs of nitrofuran antibiotics are potent GroEL/ES inhibitor pro-drugs.

von Stevens, Mckayla, Howe, Chris, Ray, Anne-Marie, Washburn, Alex, Chitre, Siddhi, Sivinski, Jared, Park, Yangshin, Hoang, Quyen Q., Chapman, Eli, Johnson, Steven M.
Veröffentlicht in Bioorg Med Chem (2020)

Constructing Kinetically Controlled Denaturation Isotherms of Folded Proteins Using Denaturant-Pulse Chaperonin Binding

von O’Neil, Pierce T., Machen, Alexandra J., Thompson, Jackie A., Wang, Wei, Hoang, Quyen Q., Baldwin, Michael R., Khar, Karen R., Karanicolas, John, Fisher, Mark T.
Veröffentlicht in Methods Mol Biol (2019)

Crystal structure of the DNA binding domain of the transcription factor T-bet suggests simultaneous recognition of distant genome sites

von Liu, Ce Feng, Brandt, Gabriel S., Hoang, Quyen Q., Naumova, Natalia, Lazarevic, Vanja, Hwang, Eun Sook, Dekker, Job, Glimcher, Laurie H., Ringe, Dagmar, Petsko, Gregory A.
Veröffentlicht in Proc Natl Acad Sci U S A (2016)

HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules

von Stevens, Mckayla, Abdeen, Sanofar, Salim, Nilshad, Ray, Anne-Marie, Washburn, Alex, Chitre, Siddhi, Sivinski, Jared, Park, Yangshin, Hoang, Quyen Q., Chapman, Eli, Johnson, Steven M.
Veröffentlicht in Bioorg Med Chem Lett (2019)

Hydroxybiphenylamide GroEL/ES inhibitors are potent antibacterials against planktonic and biofilm forms of Staphylococcus aureus.

von Kunkle, Trent, Abdeen, Sanofar, Salim, Nilshad, Ray, Anne-Marie, Stevens, Mckayla, Ambrose, Andrew J., Victorino, José, Park, Yangshin, Hoang, Quyen Q., Chapman, Eli, Johnson, Steven M.
Veröffentlicht in J Med Chem (2018)

Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections

von Washburn, Alex, Abdeen, Sanofar, Ovechkina, Yulia, Ray, Anne-Marie, Stevens, Mckayla, Chitre, Siddhi, Sivinski, Jared, Park, Yangshin, Johnson, James, Hoang, Quyen Q., Chapman, Eli, Parish, Tanya, Johnson, Steven M.
Veröffentlicht in Bioorg Med Chem Lett (2019)

Detection of ligand binding hot spots on protein surfaces via fragment-based methods: Application to DJ-1 and Glucocerebrosidase

von Landon, Melissa R., Lieberman, Raquel L., Hoang, Quyen Q., Ju, Shulin, Caaveiro, Jose M. M., Orwig, Susan D., Kozakov, Dima, Brenke, Ryan, Chuang, Gwo-Yu, Beglov, Dmitry, Vajda, Sandor, Petsko, Gregory A., Ringe, Dagmar
Veröffentlicht 2009

Parkinson's disease-associated mutations in the GTPase domain of LRRK2 impair its nucleotide-dependent conformational dynamics

von Wu, Chun-Xiang, Liao, Jingling, Park, Yangshin, Reed, Xylena, Engel, Victoria A., Hoang, Neo C., Takagi, Yuichiro, Johnson, Steven M., Wang, Mu, Federici, Mark, Nichols, R. Jeremy, Sanishvili, Ruslan, Cookson, Mark R., Hoang, Quyen Q.
Veröffentlicht in J Biol Chem (2019)

Functional Differences between E. coli and ESKAPE Pathogen GroES/GroEL

von Sivinski, Jared, Ambrose, Andrew J., Panfilenko, Iliya, Zerio, Christopher J., Machulis, Jason M., Mollasalehi, Niloufar, Kaneko, Lynn K., Stevens, Mckayla, Ray, Anne-Marie, Park, Yangshin, Wu, Chunxiang, Hoang, Quyen Q., Johnson, Steven M., Chapman, Eli
Veröffentlicht in mBio (2021)