Parkinson's disease-associated mutations in the GTPase domain of LRRK2 impair its nucleotide-dependent conformational dynamics

Mutation in leucine-rich repeat kinase 2 (LRRK2) is a common cause of familial Parkinson's disease (PD). Recently, we showed that a disease-associated mutation R1441H rendered the GTPase domain of LRRK2 catalytically less active and thereby trapping it in a more persistently “on” conformation....

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Wu, Chun-Xiang, Liao, Jingling, Park, Yangshin, Reed, Xylena, Engel, Victoria A., Hoang, Neo C., Takagi, Yuichiro, Johnson, Steven M., Wang, Mu, Federici, Mark, Nichols, R. Jeremy, Sanishvili, Ruslan, Cookson, Mark R., Hoang, Quyen Q.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6463707/
https://ncbi.nlm.nih.gov/pubmed/30796162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007631
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