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The Parkinson's disease–associated mutation N1437H impairs conformational dynamics in the G domain of LRRK2
Parkinson disease–associated mutations within the GTPase domain Ras of complex proteins (ROC) of leucine rich repeat kinase 2 (LRRK2) result in an abnormal over-activation of its kinase domain. However, the mechanisms involved remain unclear. Recent study has shown that LRRK2 G-domain cycles between...
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| Publicado no: | FASEB J |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Federation of American Societies for Experimental Biology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6988866/ https://ncbi.nlm.nih.gov/pubmed/30592623 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201802031R |
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