Učitavanje...
Parkinson disease-associated mutation R1441H in LRRK2 prolongs the “active state” of its GTPase domain
Mutation in leucine-rich-repeat kinase 2 (LRRK2) is a common cause of Parkinson disease (PD). A disease-causing point mutation R1441H/G/C in the GTPase domain of LRRK2 leads to overactivation of its kinase domain. However, the mechanism by which this mutation alters the normal function of its GTPase...
Spremljeno u:
| Glavni autori: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2014
|
| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3964117/ https://ncbi.nlm.nih.gov/pubmed/24591621 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1323285111 |
| Oznake: |
Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!
|