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Parkinson disease-associated mutation R1441H in LRRK2 prolongs the “active state” of its GTPase domain
Mutation in leucine-rich-repeat kinase 2 (LRRK2) is a common cause of Parkinson disease (PD). A disease-causing point mutation R1441H/G/C in the GTPase domain of LRRK2 leads to overactivation of its kinase domain. However, the mechanism by which this mutation alters the normal function of its GTPase...
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Main Authors: | , , , , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
National Academy of Sciences
2014
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3964117/ https://ncbi.nlm.nih.gov/pubmed/24591621 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1323285111 |
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