Parkinson disease-associated mutation R1441H in LRRK2 prolongs the “active state” of its GTPase domain

Mutation in leucine-rich-repeat kinase 2 (LRRK2) is a common cause of Parkinson disease (PD). A disease-causing point mutation R1441H/G/C in the GTPase domain of LRRK2 leads to overactivation of its kinase domain. However, the mechanism by which this mutation alters the normal function of its GTPase...

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Main Authors: Liao, Jingling, Wu, Chun-Xiang, Burlak, Christopher, Zhang, Sheng, Sahm, Heather, Wang, Mu, Zhang, Zhong-Yin, Vogel, Kurt W., Federici, Mark, Riddle, Steve M., Nichols, R. Jeremy, Liu, Dali, Cookson, Mark R., Stone, Todd A., Hoang, Quyen Q.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2014
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3964117/
https://ncbi.nlm.nih.gov/pubmed/24591621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1323285111
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