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The R1441C mutation of LRRK2 disrupts GTP hydrolysis
Mutations in Leucine Rich Repeat Kinase 2 (LRRK2) are the leading genetic cause of Parkinson’s disease (PD). LRRK2 is predicted to contain kinase and GTPase enzymatic domains, with recent evidence suggesting that the kinase activity of LRRK2 is central to the pathogenic process associated with this...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1939973/ https://ncbi.nlm.nih.gov/pubmed/17442267 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2007.04.006 |
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