THE R1441C MUTATION ALTERS THE FOLDING PROPERTIES OF THE ROC DOMAIN OF LRRK2

LRRK2 is a 250kDa multidomain protein, mutations in which cause familial Parkinson’s disease. Previously, we have demonstrated that the R1441C mutation in the ROC domain decreases GTPase activity. Here we show that the R1441C alters the folding properties of the ROC domain, lowering its thermodynami...

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Detalhes bibliográficos
Main Authors: Li, Yongchao, Dunn, Laura, Greggio, Elisa, Krumm, Brian, Jackson, Graham S., Cookson, Mark R., Lewis, Patrick A., Deng, Junpeng
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846748/
https://ncbi.nlm.nih.gov/pubmed/19781641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2009.09.010
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