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Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of Parkinson's disease (PD). LRRK2 contains a Ras of complex proteins (ROC) domain that may act as a GTPase to regulate its protein kinase activity. The structure of ROC and the mechanism(s) by which it regulates kinase...

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Detalhes bibliográficos
Main Authors: Deng, Junpeng, Lewis, Patrick A., Greggio, Elisa, Sluch, Eli, Beilina, Alexandra, Cookson, Mark R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234173/
https://ncbi.nlm.nih.gov/pubmed/18230735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709098105
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