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THE R1441C MUTATION ALTERS THE FOLDING PROPERTIES OF THE ROC DOMAIN OF LRRK2
LRRK2 is a 250kDa multidomain protein, mutations in which cause familial Parkinson’s disease. Previously, we have demonstrated that the R1441C mutation in the ROC domain decreases GTPase activity. Here we show that the R1441C alters the folding properties of the ROC domain, lowering its thermodynami...
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| Hoofdauteurs: | , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2009
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2846748/ https://ncbi.nlm.nih.gov/pubmed/19781641 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2009.09.010 |
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