Hydroxybiphenylamide GroEL/ES inhibitors are potent antibacterials against planktonic and biofilm forms of Staphylococcus aureus.

We recently reported the identification of a GroEL/ES inhibitor (1: N-(4-(benzo[d]thiazol-2-ylthio)-3-chlorophenyl)-3,5-dibromo-2-hydroxybenzamide) that exhibited in vitro antibacterial effects against Staphylococcus aureus comparable to vancomycin, an antibiotic of last resort. To follow-up, we hav...

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Pubblicato in:J Med Chem
Autori principali: Kunkle, Trent, Abdeen, Sanofar, Salim, Nilshad, Ray, Anne-Marie, Stevens, Mckayla, Ambrose, Andrew J., Victorino, José, Park, Yangshin, Hoang, Quyen Q., Chapman, Eli, Johnson, Steven M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6467803/
https://ncbi.nlm.nih.gov/pubmed/30392371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01293
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