Analogs of nitrofuran antibiotics are potent GroEL/ES inhibitor pro-drugs.

In two previous studies, we identified compound 1 as a moderate GroEL/ES inhibitor with weak to moderate antibacterial activity against Gram-positive and Gram-negative bacteria including Bacillus subtilis, methicillin-resistant Staphylococcus aureus, Klebsiella pneumonia, Acinetobacter baumannii, an...

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Publicado en:Bioorg Med Chem
Autores principales: Stevens, Mckayla, Howe, Chris, Ray, Anne-Marie, Washburn, Alex, Chitre, Siddhi, Sivinski, Jared, Park, Yangshin, Hoang, Quyen Q., Chapman, Eli, Johnson, Steven M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7914298/
https://ncbi.nlm.nih.gov/pubmed/33007545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2020.115710
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