Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy

Multiple system atrophy (MSA) is a sporadic orphan neurodegenerative disorder. No treatment is currently available to slow down the aggressive neurodegenerative process, and patients die within a few years after disease onset. The cytopathological hallmark of MSA is the accumulation of alpha-synucle...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Bassil, Fares, Fernagut, Pierre-Olivier, Bezard, Erwan, Pruvost, Alain, Leste-Lasserre, Thierry, Hoang, Quyen Q., Ringe, Dagmar, Petsko, Gregory A., Meissner, Wassilios G.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5003293/
https://ncbi.nlm.nih.gov/pubmed/27482103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1609291113
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